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HIV Infection: An Oncologic Model of Pathogenesis and Treatment

Aaron Diamond AIDS Research Center, 455 1st Avenue, 7th Floor, New York, NY 10016

	INSIGHTS INTO HIV REPLICATION IN MAN REVEAL THAT THERE ARE:

Top Insights into HIV Replication... Therapeutic Implications:

 

Rapid rounds of viral replication in vivo with large numbers of virions produced and cleared daily. This explains the prognostic power of the viral load measurement.

Slower second phase of viral decay with the identification of viral compartments and pool sizes with varying rates of decay. Can HIV be eradicated with current therapeutic approaches?

If not, are there viral compartments with slower rates of decay (i.e., CNS, testicular)?

	THERAPEUTIC IMPLICATIONS:

Top Insights into HIV Replication... Therapeutic Implications:

 

Rapid unchecked rounds of viral replication allows for the generation of genetic variants with reduced susceptibility to individual antiviral agents.

Therapy with one or even two agents selects for the emergence of multidrug resistance.

Combination antiviral therapy with three or four drugs has achieved prolonged aviremia as defined by plasma RNA and culture.

Subjects with high viral loads and prolonged courses with exposure to multiple agents introduced sequentially do worse than those with lower viral loads, minimal drug exposure and perhaps earlier aggressive intervention.

This Article Full Text (PDF) eLetters: Submit a response to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services E-mail this article link to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints/Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Markowitz, M. Search for Related Content PubMed Articles by Markowitz, M.