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The Oncologist, Vol. 12, No. 1, 51-61, January 2007; doi:10.1634/theoncologist.12-1-51
© 2007 AlphaMed Press

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 Management of Recurrent Testicular Germ Cell Tumors
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Genitourinary Cancer

Management of Recurrent Testicular Germ Cell Tumors

Guru Sonpavdea, Thomas E. Hutsona, Bruce J. Rothb

a U.S. Oncology Research, Houston, Texas, USA; b Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA

Key Words. Germ cell tumors • Salvage

Correspondence: Guru Sonpavde, M.D., 501 Medical Center Blvd., Webster, Texas 77598, USA. Telephone: 281-332-7505; Fax: 281-332-8429; e-mail: guru.sonpavde{at}usoncology.com

Although front-line chemotherapy cures most men with testicular germ cell tumors, salvage therapy is still important in a small but significant minority. Second-line conventional-dose or high-dose chemotherapy with stem cell rescue may cure 25%–50% of patients. New chemotherapeutic agents, including the taxanes gemcitabine and oxaliplatin, have added to the therapeutic armamentarium. Salvage surgical resection has an important role in selected patients. Cisplatin-refractory patients have a poor prognosis with current therapy, and novel chemotherapeutic and biologic agents need to be discovered for such patients.




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[Abstract] [Full Text] [PDF]


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